Iron chelation therapy in myelodysplastic syndrome — Cui bono?
نویسندگان
چکیده
منابع مشابه
Iron Chelation Therapy in Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are a heterogeneous disorder of the hematopoietic stem cells, frequently characterized by anemia and transfusion dependency. In low-risk patients, transfusion dependency can be long lasting, leading to iron overload. Iron chelation therapy may be a therapeutic option for these patients, especially since the approval of oral iron chelators, which are easier to use...
متن کاملMyelodysplastic Syndromes and Iron Chelation Therapy
Over recent decades we have been fortunate to witness the advent of new technologies and of an expanded knowledge and application of chelation therapies to the benefit of patients with iron overload. However, extrapolation of learnings from thalassemia to the myelodysplastic syndromes (MDS) has resulted in a fragmented and uncoordinated clinical evidence base. We're therefore forced to change o...
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Ever since Czech writer Karel Capek's well-known play " R.U.R. – Rossum's universal robots " [Capek], first published in 1920 and performed in 1921, man-made robots of human-like shape have inspired fiction writers to envision worlds with artificial creatures far superior to human beings – either in friendly coexistence or taking over by eliminating their creators and leaving them behind as an ...
متن کاملIron overload and chelation therapy in myelodysplastic syndromes.
Iron overload remains a concern in MDS patients especially those requiring recurrent blood transfusions. The consequence of iron overload may be more relevant in patients with low and intermediate-1 risk MDS who may survive long enough to experience such manifestations. It is a matter of debate whether this overload has time to yield organ damage, but it is quite evident that cellular damage an...
متن کاملImproved Survival in Patients with Myelodysplastic Syndrome Receiving Iron Chelation Therapy
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ژورنال
عنوان ژورنال: Leukemia
سال: 2009
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2009.39